Probabilistic Inference for Nucleosome Positioning with MNase-Based or Sonicated Short-Read Data
نویسندگان
چکیده
منابع مشابه
Probabilistic Inference for Nucleosome Positioning with MNase-Based or Sonicated Short-Read Data
We describe a model-based method, PING, for predicting nucleosome positions in MNase-Seq and MNase- or sonicated-ChIP-Seq data. PING compares favorably to NPS and TemplateFilter in scalability, accuracy and robustness to low read density. To demonstrate that PING predictions from widely available sonicated data can have sufficient spatial resolution to be to be useful for biological inference, ...
متن کاملPING 2.0: an R/Bioconductor package for nucleosome positioning using next-generation sequencing data
SUMMARY MNase-Seq and ChIP-Seq have evolved as popular techniques to study chromatin and histone modification. Although many tools have been developed to identify enriched regions, software tools for nucleosome positioning are still limited. We introduce a flexible and powerful open-source R package, PING 2.0, for nucleosome positioning using MNase-Seq data or MNase- or sonicated- ChIP-Seq data...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0032095